PREDICTION OF INDIVIDUAL DIFFERENCES IN POSTIRRADIATION REGENERATION OF THE LYMPHATIC TISSUE OF THE THYMUS

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Folia Biologica (Prague) (Czechoslovakia)

OSTI ID:4635620

Pospisil, M

Individual variations in the excretion of sodium and potassium in the urine (the Na/K ratio of mice starved for 24 hours and kept in metabolic cages) was found to be a suitable criterion for evaluating the degree of regeneration of the lymphatic tissue of the thymus, which was studied on the seventh and tenth day after irradiation with a single whole body dose of 100 r. Comparison of the two sets of values was based on the difference in the Na/K ratio 24 hours before killing the experimental animals and the values determined 24 hours before irradiation. The rate of regeneration of the lymphatic tissue of the thymus was higher in animals in which this difference was low and high. Changes in the Na/K ratio after irradiation as compared with the initial pre-irradiation values are regarded as the quantitative expression of the efforts of the organism to maintain homoeostasis. A low and high degree of mobility of this parameter is thus accompanied by higher regenerative capacity of the lymphatic tissue of the irradiated organism. The methodological significance of this finding for the interindividual differentiation of the reaction of experimental animals to irradiation is emphasized. (auth)

• Research Organization: Inst. of Biophysics, Czechoslovak Academy of Sciences, Brno
• NSA Number: NSA-17-040584
• OSTI ID: 4635620
• Journal Information: Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 9; ISSN FOBLA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
DIET
IRRADIATION
LYMPH SYSTEM
METABOLISM
POTASSIUM
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY
REGENERATION
SODIUM
THYMUS
TISSUES
URINE
VARIATIONS