X-ray induced Chromosomal Aberrations in Rice Plants
The effect of gamma -irradiation on the phosphorus (acid soluble fractions) metabolism of mouse strain L cells in culture was studied in an attempt to shed light on the mechanisms of radiation inhibition of cell multiplication. Content and incorporation of P/sup 32/ into the acid-soluble fractions of the cells were measured following a Co/sup 60/ gamma dose of 2000 r, the dose known to yield 50% inhibition of cell multiplication. Phosphorus-32 incorporated into each compound was measured with a Geiger-Muller counter, and the phosphorus content of each compound was derived by the method of Horecker slightly modified. Significant decrease in P/sup 32/ incorporation was noted in the fractions containing CMP (calcium metaphosphate), DPN (diphosphopyridine nucleotide), and adenine compounds such as ATP (adenosine triphosphate), ADP (adenosine monophosphate), and AMP (adenosine monophosphate). However, no significant phosphorus decrease was observed in ATP, ADP, or AMP. An increase in P/sup 32/ incorporation was noted in the inorganic phosphate fraction. It is concluded that the processes of oxidative phosphorylation with its concurrent formation of high energy phosphorus compound have been primarily damaged by gamma -irradiation. The correlation observed between the inhibition of cell division and the reduction in the formation of high energy phosphorus compounds may provide a clue for resolution of the nature of cell division and the effects of radiation on it. (H.M.G.)
- Research Organization:
- Kyushu Univ., Fukuoka, Japan
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-037089
- OSTI ID:
- 4631162
- Journal Information:
- Idengaku Zasshi, Journal Name: Idengaku Zasshi Journal Issue: 1 Vol. 38; ISSN 0021-504X
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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