MOLECULAR RADIOBIOLOGY OF HUMAN CELL LINES. V. COMPARATIVE RADIOSENSITIZING PROPERTIES OF 5-HALODEOXYCYTIDINES AND 5-HALODEOXYURIDINES

Journal Article · Tue Oct 01 04:00:00 EDT 1963 · Radiation Res.

DOI:https://doi.org/10.2307/3571531· OSTI ID:4618659

Erikson, R L; Szybalski, W

Under identical conditions, 5-bromo derivatives of deoxyuridine (BUdR) and deoxycytidine (BCdR) are incorporated to the same extent into the DNA of the human cell line D98/AG, producing approximately equal degrees of radiosensitization. An analogous conclusion holds true for 5iododeoxyuridine (IUdR) and 5-iododeoxycytldine (ICdR), although the iodo analogs are less effectively incorporated into DNA than the bromo analogs. For the same degree of thymidine replacement, bromo derivatives are only slightly better ultraviolet light sensitizers than the iodo derivatives; on the other hand, the latter are much better x-ray sensitizers than the former. For all the compounds, but especially for the bromo analogs, the sensitization toward ultraviolet light is more pronounced than toward x rays. The x-ray sensitization by halo analogs does not seem to depend on the comparatively higher photoelectric absorption cross section of the halogen atoms, since the degree of sensitization is independent of the energy of the x rays. (auth)

• Research Organization: Univ. of Wisconsin, Madison
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-040613
• OSTI ID: 4618659
• Journal Information: Radiation Res., Journal Name: Radiation Res. Vol. Vol: 20
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ABSORPTION
ANIMAL CELLS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BROMINATED HYDROCARBONS
CROSS SECTIONS
CYTIDINE
DNA
EFFICIENCY
ENERGY
HETEROCYCLICS
MAN
NUCLEIC ACIDS
ORGANIC BROMINE COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOBIOLOGY
RADIOSENSITIVITY
REACTION KINETICS
THYMIDINE
ULTRAVIOLET RADIATION
URIDINE
X RADIATION