Designed supramolecular assemblies for biosensors and photoactive devices. LDRD final report
The objective of this project is the development of a new class of supramolecular assemblies for applications in biosensors and biodevices. The supramolecular assemblies are based on membranes and Langmuir-Blodgett (LB) films composed of naturally-occurring or synthetic lipids, which contain electrically and/or photochemically active components. The LB films are deposited onto electrically-active materials (metal, semiconductors). The active components film components (lipo-porphyrins) at the surface function as molecular recognition sites for sensing proteins and other biomolecules, and the porphyrins and other components (e.g., fullerenes) incorporated into the films serve as photocatalysts and vectorial electron-transport agents. Computer-aided molecular design (CAMD) methods are used to tailor the structure of these film components to optimize function. Molecular modeling is also used to predict the location, orientation, and motion of these molecular components within the films. The result is a variety of extended, self-assembled molecular structures that serve as devices for sensing proteins and biochemicals or as other bioelectronic devices.
- Research Organization:
- Sandia National Labs., Albuquerque, NM (United States)
- Sponsoring Organization:
- USDOE Office of Financial Management and Controller, Washington, DC (United States)
- DOE Contract Number:
- AC04-94AL85000
- OSTI ID:
- 461263
- Report Number(s):
- SAND--97-0258; ON: DE97005177
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
44 INSTRUMENTATION
INCLUDING NUCLEAR AND PARTICLE DETECTORS
55 BIOLOGY AND MEDICINE
BASIC STUDIES
CYTOCHROMES
DESIGN
DETECTION
ELECTRON TRANSFER
LIPIDS
MEMBRANES
MOLECULAR STRUCTURE
NICKEL COMPOUNDS
PHOTOCHEMICAL REACTIONS
PORPHYRINS
PROBES
PROTEINS
SURFACE PROPERTIES
THIN FILMS