Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor Toll, to human chromosome 4p14

Journal Article · Tue Mar 05 00:00:00 EST 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0150· OSTI ID:459022

Taguchi, Takahiro; Testa, J R ^[1]; Mitcham, J L; Dower, S K; Sims, J E ^[2]

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1. Fox Chase Cancer Center, Philadelphia, PA (United States)
2. Immunex Corp., Seattle, WA (United States)

This report describes the localization of the the TIL gene to human chromosome 4p14 using fluorescence in situ hybridization. This gene encodes a protein which is related to the Drosophila transmembrane receptor Toll and the mammalian interleukin-1 receptor, which share similarities in structure and function. The Drosophila gene is also important during embryonic development, which makes TIL a candidate locus for human congenital malformations that are genetically linked to human chromosome 4. 17 refs., 1 fig.

• OSTI ID: 459022
• Journal Information: Genomics, Vol. 32, Issue 3; Other Information: PBD: 5 Mar 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
MEMBRANE PROTEINS
RECEPTORS
GENES
STRUCTURE-ACTIVITY RELATIONSHIPS
DNA SEQUENCING
GENETIC MAPPING
HUMAN CHROMOSOMES
LYMPHOKINES
CONGENITAL MALFORMATIONS
GENETICS
HUMAN CHROMOSOME 2
DROSOPHILA
DNA HYBRIDIZATION
FLUORESCENCE
AMINO ACID SEQUENCE
HEREDITARY DISEASES
ONTOGENESIS
PROBES