Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor Toll, to human chromosome 4p14

Journal Article · Mon Mar 04 23:00:00 EST 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0150· OSTI ID:459022

Taguchi, Takahiro; Testa, J R ^[1]; Mitcham, J L; Dower, S K; Sims, J E ^[2]

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1. Fox Chase Cancer Center, Philadelphia, PA (United States)
2. Immunex Corp., Seattle, WA (United States)

This report describes the localization of the the TIL gene to human chromosome 4p14 using fluorescence in situ hybridization. This gene encodes a protein which is related to the Drosophila transmembrane receptor Toll and the mammalian interleukin-1 receptor, which share similarities in structure and function. The Drosophila gene is also important during embryonic development, which makes TIL a candidate locus for human congenital malformations that are genetically linked to human chromosome 4. 17 refs., 1 fig.

• OSTI ID: 459022
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 32; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMINO ACID SEQUENCE
CONGENITAL MALFORMATIONS
DNA HYBRIDIZATION
DNA SEQUENCING
DROSOPHILA
FLUORESCENCE
GENES
GENETIC MAPPING
GENETICS
HEREDITARY DISEASES
HUMAN CHROMOSOME 2
HUMAN CHROMOSOMES
LYMPHOKINES
MEMBRANE PROTEINS
ONTOGENESIS
PROBES
RECEPTORS
STRUCTURE-ACTIVITY RELATIONSHIPS