Magnetic resonance imaging (MRI) detection of the murine brain response to light: Temporal differentiation and negative functional MRI changes
- State Univ. of New York, Stony Brook, NY (United States)
- State Univ. of New York, Stony Brook, NY (United States); and others
Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30%) are consistent with literature results extrapolated to 9.4 T. However, there are also two unusual aspects to our findings. (i) The visual area of the brain responds only to changes in stimulus intensity, suggesting that we directly detect operations of the M visual system pathway. Such a channel has been observed in mice by invasive electrophysiology, and described in detail for primates. (ii) Along with the typical positive response in the area of the occipital portion of the brain containing the visual cortex; another area displays decreased signal intensity upon stimulation. 41 refs., 4 figs.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 457016
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 12; Other Information: PBD: 11 Jun 1996
- Country of Publication:
- United States
- Language:
- English
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