{delta}-Aminolevulinic acid dehydratase activity in weanling and adult rats exposed to lead acetate

Journal Article · Mon Jul 01 00:00:00 EDT 1996 · Bulletin of Environmental Contamination and Toxicology

DOI:https://doi.org/10.1007/s001289900154· OSTI ID:456754

Rodrigues, A L.S. ^[1]; Rocha, J B.T.; Pereira, M E ^[2]; Souza, D O ^[3]

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1. Universidade Federal de Santa Catarina, Florianopolis (Brazil)
2. Universidade Federal de Santa Maria (Brazil)
3. Universidade Federal do Rio Grande do Sul, Porto Alegre (Brazil)

Lead is an environmental pollutant with no known beneficial health effects, and environmental or occupational exposure to this metal is known to result in toxicity. It may affect numerous organ systems, including the renal, reticuloendothelial, reproductive, and nervous system. Children and young animals are particularly sensitive to the toxic effects of this metal, being the central nervous system the main target of lead toxicity. Adults seem to be more resistant to lead neurotoxicity, but lead nephrotoxicity is a prominent effect. This study compares lead effects of forebrain, cerebellar, and renal ALAD activity and the reactivation index with DTT obtained from prenatal and lactational lead-exposure of rats and prenatal, lactational, and long-term post lactational lead exposure of rats. 16 refs., 3 tabs.

• OSTI ID: 456754
• Journal Information: Bulletin of Environmental Contamination and Toxicology, Vol. 57, Issue 1; Other Information: PBD: Jul 1996
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
LEAD
BIOLOGICAL EFFECTS
AMINOLEVULINIC ACID
BIOCHEMISTRY
RATS
CENTRAL NERVOUS SYSTEM