Evaluation of models for predicting the phototoxicity potency of polycyclic aromatic hydrocarbons

Conference · Sun Dec 31 04:00:00 EST 1995

OSTI ID:455333

Erickson, R J; Ankley, G T; Sheedy, B R; Kosian, P A; Mattson, V R; Cox, J S; Defoe, D L ^[1]

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1. Environmental Protection Agency, Duluth, MN (United States)

The acute phototoxicities of selected polycyclic aromatic hydrocarbons (PAHs) to the oligochaete Lumbriculus variegatus were investigated in order to evaluate a predictive structure/activity relationship (SAR) for the phototoxic potential of PAHs and to determine the relationship of phototoxicity to PAH accumulation, light intensity, and exposure duration. Test organisms were exposed to multiple concentrations of anthracene, pyrene, fluorene, and fluoranthene in water for 96 h and then to various intensities of ultraviolet light for 96 h in clean water. In agreement with the SAR model, fluorene was not phototoxic while pyrene, fluoranthene, and anthracene were. Based upon measured accumulations of PAHs, anthracene and pyrene had similar potencies, and both were 3--4 fold more toxic than fluoranthene. Time-to-death was found to adhere well to a model based on damage accumulating as a function of the product of chemical accumulation and light intensity. Additivity of PAH phototoxicity was evaluated in exposures using mixtures of these chemicals.

• OSTI ID: 455333
• Report Number(s): CONF-961149--
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ANNELIDS
ANTHRACENE
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
CONDENSED AROMATICS
FLUORENE
MATHEMATICAL MODELS
PHOTOCHEMICAL REACTIONS
PYRENE
STRUCTURE-ACTIVITY RELATIONSHIPS
TOXICITY
ULTRAVIOLET RADIATION
WATER POLLUTION