Clinical PET using a remote cyclotron: Use of copper-62 PTSM in patients with colorectal liver metastases
- Institute of Cancer Research/Royal Marsden NHS Trust, Sutton (United Kingdom)
Clinical PET with generator-produced radiopharmaceutical is a viable option for PET centres without an on-site cyclotron. In view of the practical constraints imposed by the short half-lives of the Zn-62 (9.3 hr) parent and the Cu-62 (9.7 min) daughter, the objectives of this study were: (1) the preparation of in-house clinical Zn-62/ Cu-62 generators produced form targets irradiated at a remote cyclotron, (2) the optimisation of acquisition parameters for Cu-62 imaging with MUP-PET camera and (3) to evaluate the use of Cu-62-pyruvaldehyde bis(N4-methylthiosemicarbazone) (Cu-62-PTSM) in assessing blood flow changes induced by angiotensin II (AII) infusion in patients with colorectal liver metastases (CLM). Zn-62 was produced by bombardment of natural Cu targets at a remote cyclotron and the activity processed, in house, using anion-exchange chromatography techniques as previously reported. High activity (2.5-4.5 GBq) generators were prepared from which clinical grade Cu-62-PTSM doses were produced over a 3 day period. Eight patients undergoing regional fluorodeoxyuridine (FUdR) chemotherapy received regional administration of Cu-62-PTSM on three occasions before during and after a 40 min. AII infusion. Distribution of the radiotracer was measured using the MUP-PET camera. In seven of these patients an increase in the ratio of tumour to normal liver blood flow was demonstrated during AII infusion. This effect was prolonged and was sustained throughout the infusion period. This is the first clinical PET study to demonstrate an increase in relative tumour blood flow in patients with CLM during prolonged infusion of a vasoactive agent. Using generator-produced and medium half-life radiotracers, clinical PET is a workable alternative to short-lived racers from an on-site cyclotron.
- OSTI ID:
- 447749
- Report Number(s):
- CONF-960659-; ISSN 0161-5505; TRN: 97:000961-0029
- Journal Information:
- Journal of Nuclear Medicine, Vol. 37, Issue Suppl.5; Conference: 43. annual meeting of the Society of Nuclear Medicine, Denver, CO (United States), 3-6 Jun 1996; Other Information: PBD: May 1996
- Country of Publication:
- United States
- Language:
- English
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