Hematologic toxicity in radioimmunotherapy: An evaluation of different predictive measures

Journal Article · Wed May 01 04:00:00 EDT 1996 · Journal of Nuclear Medicine

OSTI ID:447732

Sgouros, G; Divgi, C; Scott, A M ^[1]

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1. Memorial Sloan-Kettering Cancer Center, New York, NY (United States); and others

In essentially all cases of intravenously administered administered radiolabeled antibody, hematologic toxicity has limited the amount of radioactivity that may be administered. In this study 4 potential predictors of hematologic toxicity are evaluated: red marrow dose (RMD), whole-body dose (WBD), administered activity (AA), and administered activity per unit surface area (AASA). These were evaluated against 8 measures of hematologic toxicity: grade (G), time-to-nadir (TTN), and absolute and per cent drop in counts (ADC, %DC) for platelets (P) and white blood cells (W). Data from a phase I study of 29 patients with metastatic colon carcinoma and a total of 35 different antibody administrations of {sup 131}I-CC49 antibody were used in the analysis. Serum clearance kinetics were used to estimate RMD. A remainder-of-body term representing activity not in the red marrow was included in the RMD calculations. The whole-body dose was estimated as the product of whole-body cumulated activity, derived form survey meter measurements, and the whole-body to whole-body S-factor. All S-factors were obtained from MIRD Pamphlet 11. Patient surface area was estimated form each patient`s height and weight. Patients exhibiting accelerated clearance kinetics due to an immunologic response against the antibody (HAMA) were included in the analysis. The correlation coefficients, r, are listed in the table. All patients had been treated with 5-FU and leucovorin previously. When patients that has also been treated with mitomycin and/or alkylating agents were excluded from the analysis, the r values shown on the last line of the table were obtained for platelet toxicity grade. These results suggest that, although still poor, RMD may be a slightly better predictor of toxicity than other measures.

• OSTI ID: 447732
• Report Number(s): CONF-960659--
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 37; ISSN 0161-5505; ISSN JNMEAQ
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BLOOD CELLS
CARCINOMAS
CLEARANCE
IODINE 131
LARGE INTESTINE
MEASURING METHODS
MITOMYCIN
PATIENTS
RADIATION DOSES
RADIOIMMUNOTHERAPY
TOXICITY