Apolipoprotein E genotype in schizophrenia
- McGill Research Centre for Schizophrenia, Douglas Hospital, Montreal (Canada); and others
We investigated the association between schizophrenia and the allelic polymorphism in the apolipoprotein E (Apo E) gene in 51 schizophrenic patients and 35 controls. The Apo E4 allele was equally represented in the schizophrenic group (16%) and the control group (20%) suggesting no association between schizophrenia and the Apo E4 allele. The apolipoprotein E (Apo E) is a polymorphic (E2, E3, and E4) lipoprotein involved in the transmembrane transport of cholesterol and is thought to play an important role in neuronal growth and in the central nervous system response to injury, particularly in the hippocampal region. Recent findings strongly suggest that the Apo E4 allele is associated with cognitive deficits in normal and pathological aging, e.g., Alzheimer`s disease. 5 refs., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 447669
- Journal Information:
- American Journal of Medical Genetics, Vol. 67, Issue 2; Other Information: PBD: 9 Apr 1996
- Country of Publication:
- United States
- Language:
- English
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