Analysis of thirteen trinucleotide repeat loci as candidate genes for Schizophrenia and bipolar affective disorder

Journal Article · Tue Apr 09 04:00:00 EDT 1996 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19960409)67:2<139::AID-AJMG3>3.3.CO;2-O· OSTI ID:447656

Jain, S; Leggo, J; Ferguson-Smith, M A; Rubinsztein, D C ^[1]

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1. Addenbrooke`s NHS Trust, Cambridge (United Kingdom); and others

A group of diseases are due to abnormal expansions of trinucleotide repeats. These diseases all affect the nervous system. In addition, they manifest the phenomenon of anticipation, in which the disease tends to present at an earlier age or with greater severity in successive generations. Many additional genes with trinucleotide repeats are believed to be expressed in the human brain. As anticipation has been reported in schizophrenia and bipolar affective disorder, we have examined allele distributions of 13 trinucleotide repeat-containing genes, many novel and all expressed in the brain, in genomic DNA from schizophrenic (n = 20-97) and bipolar affective disorder patients (23-30) and controls (n = 43-146). No evidence was obtained to implicate expanded alleles in these 13 genes as causal factors in these diseases. 26 refs., 1 fig., 2 tabs.

• OSTI ID: 447656
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 2 Vol. 67; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AGE DEPENDENCE
GENE MUTATIONS
GENE REGULATION
GENES
GENETIC MAPPING
HEREDITARY DISEASES
MENTAL DISORDERS
NERVOUS SYSTEM DISEASES
NUCLEOTIDES
PATIENTS
POLYMERASE CHAIN REACTION