Linkage mapping of the angiotensin AT{sub 2} receptor gene (Agtr2) to the mouse X chromosome
- Stanford Univ. School of Medicine, CA (United States)
Angiotensin II is a potent regulator of cardiovascular homeostasis and binds to two different G-protein-coupled receptors. While the type 1 receptor (AT{sub 1}) mediates the cardiovascular actions of angiotensin II, the function of the recently cloned type 2 receptor (AT{sub 2}) remains unknown. We have cloned the mouse AT{sub 2} receptor gene (Agtr2) and determined its map position by linkage analysis using an interspecific backcross (C57BIJ6J x Mus spretus). Agtr2 is located on the proximal mouse X chromosome between MMU85 and DMVU49, in a region of conserved synteny with a part of the human X chromosome implicated in inherited forms of premature ovarian failure. The mapping of Agtr2 may expand a region of conserved synteny with human Xq26 that includes Hprt. 24 refs., 2 figs.
- OSTI ID:
- 446986
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 2 Vol. 30; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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