Genomic organization of the mouse fibroblast growth factor receptor 3 (Fgfr3) gene
- Los Alamos National Lab., NM (United States)
The fibroblast growth factor receptor 3 (Fgfr3) protein is a tyrosine kinase receptor involved in the signal transduction of various fibroblast growth factors. Recent studies suggest its important role in normal development. In humans, mutation in Fgfr3 is responsible for growth disorders such as achondroplasia, hypoachondroplasia, and thanatophoric dysplasia. Here, we report the complete genomic organization of the mouse Fgfr3 gene. The murine gene spans approximately 15 kb and consists of 19 exons and 18 introns. One major and one minor transcription initiation site were identified. Position +1 is located 614 nucleotides upstream from the ATG initiation codon. The translation initiation and termination sites are located in exons 2 and 19, respectively. Five Sp1 sites, two AP2 sites, one Zeste site, and one Krox 24 site were observed in the 5{prime}-flanking region. The Fgfr3 promoter appears to be contained within a CpG island and, as is common in genes having multiple Sp1-binding sites, lacks a TATA box. 35 refs., 3 figs., 1 tab.
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 446958
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 2 Vol. 30; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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BASIC STUDIES
AMINO ACID SEQUENCE
CODONS
CONGENITAL DISEASES
CONGENITAL MALFORMATIONS
DNA SEQUENCING
ETIOLOGY
EXONS
FIBROBLASTS
GENE MUTATIONS
GENETIC MAPPING
GROWTH FACTORS
HEREDITARY DISEASES
MICE
NUCLEOTIDES
PHOSPHOTRANSFERASES
PROTEINS
RECEPTORS
STRUCTURE-ACTIVITY RELATIONSHIPS
TRANSCRIPTION
TYROSINE