The human FGF9 gene maps to chromosomal region 13q11-q12
- U.242 Inserm, Marseille (France); Institut Paoli-Calmettes, Marseille (France)
- U.119 Inserm, Marseille (France)
The FGF gene family (fibroblast growth factor) currently comprises nine members: FGF1 to FGF9. FGFs are peptide regulatory factors acting through four distinct tyrosine kinase receptors and involved in various biological processes during embryogenesis and adult life, including implantation, morphogenesis, angiogenesis, and possibly tumorigensis. To date the chromosomal localizations of only seven human FGF and eight mouse Fgf genes are known. They are localized in various areas of the human and mouse genomes, except for FGF3 and FGF4, which are tandemly linked on chromosome 11 in humans and 7 in mice. The determination of the chromosomal localization of FGF and FGF receptor genes has often been instrumental in linking human disease or mouse spontaneous mutations to molecular alterations and is therefore of particular interest. Radioactive chromosomal in situ hybridization was used to map the most recently isolated member of the family, FGF9, in the human genome. The probe for FGF9 was pFGF9-FP, a plasmid containing a 0.5-kb product of amplification by polymerase chain reaction derived from our previous experiments and subcloned into a Bluescript vector. In situ hybridization was performed according to published procedures. 9 refs., 1 fig.
- OSTI ID:
- 443891
- Journal Information:
- Genomics, Vol. 29, Issue 3; Other Information: PBD: 10 Oct 1995
- Country of Publication:
- United States
- Language:
- English
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