Genetic and phenotypic heterogeneity of human malignancies: Finding order in chaos
- Allegheny-Singer Research Institute, Pittsburgh, PA (United States)
- Loyola Univ. Medical Center, Maywood, IL (United States)
The presence of cellular heterogeneity within human tumors has been recognized for many years. Current concepts regarding the clonal origin of human neoplasms, and recent advances in the study of successive genetic changes that occur during tumor evolution may now make it possible to understand in greater depth the biological and clinical implications of intra-tumor heterogeneity at both the phenotypic and genotypic levels. In order to explore these concepts further, and to better identify the potential contributions that flow and image cytometry can make to our understanding of tumor heterogeneity, a session of the 1994 ISAC Congress was dedicated to plenary presentations on human cancer cell heterogeneity. Here, we provide a brief overview of the genetic evolutionary progression of human cancers, some considerations of clinically important phenotypic and genotypic markers, and an outline that might serve as a basis for framing relevant issues that are ammenable to further study. 21 refs., 1 fig.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 443393
- Journal Information:
- Cytometry, Vol. 21, Issue 1; Other Information: PBD: 1 Sep 1995
- Country of Publication:
- United States
- Language:
- English
Similar Records
Stable microsatellite length but frequent allele loss in SV40-immortalized Werner syndrome and control cell lines
Phenotype heterogeneity in cancer cell populations