Survival and endogenous colony formation in irradiated mice grafted with normal or infectious mononucleosis bone marrow
Mice were exposed to 850 or 975 rad of whole-body radiation; three hr later mice were given normal human bone marrow, infectious mononucleosis bone marrow, or cells from malignant blood diseases. The surviving mice were killed at day 9 and the spleen nodules were counted. Some mice were also given antihuman antilymphocytic serum (ALS). In mice exposed to 975 rad, the highest survival was observed in mice grafted with infectious mononucleosis bone marrow, while none of the animals grafted with cells from malignant blood diseases survived 9 days. In mice exposed to 850 rad, grafting of normal or infectious mononucleosis bone marrow markedly decreased the survival. Endogenous spleen colonies were induced in all animals grafted with normal or infectious mononucleosis bone marrow. (HLW)
- Research Organization:
- Catholic Univ., Louvain, Belgium
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-29-000755
- OSTI ID:
- 4419928
- Journal Information:
- Experientia, Vol. 29, Issue 7; Other Information: Orig. Receipt Date: 30-JUN-74; ISSN 0014-4754
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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