Survival and endogenous colony formation in irradiated mice grafted with normal or infectious mononucleosis bone marrow

Journal Article · Sun Jul 01 04:00:00 EDT 1973 · Experientia

DOI:https://doi.org/10.1007/BF01946331· OSTI ID:4419928

Louwagie, A. C.; Verwilghen, R. L.

Mice were exposed to 850 or 975 rad of whole-body radiation; three hr later mice were given normal human bone marrow, infectious mononucleosis bone marrow, or cells from malignant blood diseases. The surviving mice were killed at day 9 and the spleen nodules were counted. Some mice were also given antihuman antilymphocytic serum (ALS). In mice exposed to 975 rad, the highest survival was observed in mice grafted with infectious mononucleosis bone marrow, while none of the animals grafted with cells from malignant blood diseases survived 9 days. In mice exposed to 850 rad, grafting of normal or infectious mononucleosis bone marrow markedly decreased the survival. Endogenous spleen colonies were induced in all animals grafted with normal or infectious mononucleosis bone marrow. (HLW)

• Research Organization: Catholic Univ., Louvain, Belgium
• Sponsoring Organization: USDOE
• NSA Number: NSA-29-000755
• OSTI ID: 4419928
• Journal Information: Experientia, Journal Name: Experientia Journal Issue: 7 Vol. 29; ISSN 0014-4754
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*RADIATION SYNDROME-- SURVIVAL TIME
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
IMMUNE SERUMS
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
RADIATION DOSES
RADIATIONS
RESPONSE MODIFYING FACTORS
SPLEEN
SPLEEN COLONY FORMATION
TRANSPLANTS
WHOLE- BODY IRRADIATION