Increased epidermal deoxyribonuclease I activity in $beta$-irradiated guinea pig skin. Irradiation through the hair, a required control
Within 24 h after close clipping of guinea pig hair there is dramatic increase in epidermal deoxyribonuclease 1 (DNase I) and the enzyme can be washed from the skin surface with 0.14 M NaCl or from excised epidermis prior to homogenization. In order to study changes in DNase I activity as a result of BETA -irradiation injury it was necessary to irradiate through the hair of one flank with 4700 rep BETA (/sup 90/Sr-- /sup 90/Y). These changes were compared with those after a contact dose of 3000 rep BETA given to the closely clipped skin surface on the other flank. Extracellular epidermal DNase I increased significantly on days 10 and 15 postirradiation in both flanks; however, there was a 3- to 4-fold greater concentration on the flank from which the hair had been clipped prior to irradiation. The possible mechanisms for the increase in epidermal DNase I are discussed. (auth)
- Research Organization:
- Albert Einstein Medical Center, Philadelphia
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-29-000763
- OSTI ID:
- 4419843
- Journal Information:
- Arch. Dermatol. Forsch., no. 247, pp. 65-71, Journal Name: Arch. Dermatol. Forsch., no. 247, pp. 65-71; ISSN ADMFA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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