In vitro models of cellular immunity: the role of T and B cells in the secretion of lymphotoxin

Journal Article · Mon Jan 01 04:00:00 EST 1973 · Cell. Immunol., v. 7, pp. 313-321

DOI:https://doi.org/10.1016/0008-8749(73)90253-0· OSTI ID:4394461

Shacks, S J; Chiller, J; Granger, G A

When normal murine spleen cells were treated with anti-theta serum and complement, they failed to produce LT or synthesize cellular DNA when stimulated in vitro with PHA. Theta-positive cells were responsible for LT production in spleens removed from x-irradiated and bone marrow- or thymus-reconstituted animals. Finally, spleens from congenitally athymic Nu/Nu mice failed to produce LT when stimulated with pokeweed mitogen or phytohemagglutinin. (auth)

• Research Organization: Univ. of California, Irvine
• Sponsoring Organization: USDOE
• NSA Number: NSA-29-000751
• OSTI ID: 4394461
• Journal Information: Cell. Immunol., v. 7, pp. 313-321, Journal Name: Cell. Immunol., v. 7, pp. 313-321; ISSN CLIMB
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*IMMUNITY-- BIOLOGICAL RADIATION EFFECTS
*TOXINS-- BIOSYNTHESIS
BIOLOGICAL MODELS
BLOOD SERUM
BONE MARROW
DNA
IN VITRO
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHOTON BEAMS
PHYTOHEMAGGLUTININ
SPLEEN
SPLEEN CELLS
THYMUS
X RADIATION SPLEEN CELLS