Systematic chromosome examination of two families with schizophrenia and two families with manic depressive illness

Journal Article · Fri Feb 16 04:00:00 EST 1996 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19960216)67:1<58::AID-AJMG10>3.3.CO;2-6· OSTI ID:437198

Friedrich, U; Mors, O; Ewald, H ^[1]

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1. Aarhus Univ. (Denmark)

Systematic and detailed chromosome analysis, combined with a semistructured interview, was performed in 2 families with schizophrenia and in 2 families with manic depressive illness. Prometaphase technique did not reveal any subtle structural chromosome abnormalities. However, in standard techniques, gain and loss of sex chromosomes were observed. This occurred in patients at a younger age than in unaffected persons. This gives rise to the suspicion that sex chromosome aneuploidy may somehow be related to the development of psychosis. But since the data set is small, especially with respect to schizophrenia, further studies are needed to elucidate this observation. In one family, cosegregation of the disease locus with a marker on chromosome 21 was seen. Therefore, further research should determine if chromosome 21 contains a gene for manic depressive illness. 10 refs., 3 figs., 2 tabs.

• OSTI ID: 437198
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 1 Vol. 67; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AGE DEPENDENCE
ANEUPLOIDY
BIOLOGICAL MARKERS
CHROMOSOMAL ABERRATIONS
DETECTION
GENES
GENETIC MAPPING
GENETICS
HEREDITARY DISEASES
HETEROCHROMOSOMES
HUMAN CHROMOSOME 21
HUMAN CHROMOSOMES
MENTAL DISORDERS
NERVOUS SYSTEM DISEASES
PATIENTS