DLG1: Chromosome location of the closest human homologue of the Drosophila discs large tumor suppressor gene

Journal Article · Sun Dec 10 04:00:00 EST 1995 · Genomics

DOI:https://doi.org/10.1006/geno.1995.1286· OSTI ID:437183

Azim, A C; Marfatia, S M; Chishti, A H ^[1]

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1. Tufts Univ., Boston, MA (United States); and others

The Drosophila discs large tumor suppressor protein, Dlg, is the prototype of a newly discovered family of proteins termed MAGUKs (membrane-associated guanylate kinase homologues). MAGUKs are localized at the membrane-cytoskeleton interface, usually at cell-cell junctions, where they appear to have both structural and signaling roles. They contain several distinct domains, including a modified guanylate kinase domain, an SH3 motif, and one or three copies of the DHR (GLGF/PDZ) domain. Recessive lethal mutations in the discs large tumor suppressor gene interfere with the formation of septate junctions (thought to be the arthropod equivalent of tight junctions) between epithelial cells, and they cause neoplastic overgrowth of imaginal discs, suggesting a role for cell junctions in proliferation control. A homologue of the Dlg protein, named Hdlg, has been isolated from human B lymphocytes. It shows 65-79% identity to Dlg in the different domains, and it binds to the cytoskeletal protein 4.1. Here, we report that the gene for lymphocyte Hdlg, named DLG1, is located at chromosome band 3q29. This finding identifies a novel site for a candidate tumor suppressor on chromosome 3. 33 refs., 2 figs.

• OSTI ID: 437183
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 30; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
CELL PROLIFERATION
CHROMOSOMES
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-CLONING
DROSOPHILA
GENETIC MAPPING
HEREDITARY DISEASES
HUMAN CHROMOSOME 3
LETHAL MUTATIONS
NEOPLASMS
PHOSPHOTRANSFERASES
PROTEINS
RECESSIVE MUTATIONS
STRUCTURE-ACTIVITY RELATIONSHIPS