Cadmium concentrations in the brains of Alzheimer cases

Journal Article · Tue Dec 31 04:00:00 EST 1996 · Transactions of the American Nuclear Society

OSTI ID:436776

Spyrou, N M; Stedman, J D ^[1]

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1. Univ. of Surrey, Guildford (United Kingdom)

There is ongoing research in relating the concentration of elements in the brain with Alzheimer`s disease. The presence of particular elements, such as aluminum and vanadium, has been considered as a possible environmental factor, creating significant interest and controversy in the field. We have been analyzing brain tissue from the MRC Alzheimer`s Disease Brain Bank, Institute of Psychiatry, from a number of cortical regions of the brain, namely, the frontal, occipital, parietal, and temporal lobes, as well as from the left and right hemispheres of the same brain whenever possible. The techniques employed have been proton-induced X-ray emission (PIXE) analysis, proton-induced gamma-ray emission (PIGE) analysis, Rutherford backscattering (RBS), and instrumental neutron activation analysis. Neutron irradiations were carried out at the Imperial College Consort II reactor, whereas for PIXE, PIGE, and RBS, the University of Surrey Accelerator Laboratories were used employing a Van de Graaff accelerator. In this paper, we present the cadmium results from the frontal lobe of Alzheimer cases and controls determined by PIXE analysis.

• OSTI ID: 436776
• Report Number(s): CONF-9606116--
• Journal Information: Transactions of the American Nuclear Society, Journal Name: Transactions of the American Nuclear Society Vol. 74; ISSN 0003-018X; ISSN TANSAO
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
55 BIOLOGY AND MEDICINE
BASIC STUDIES
ABUNDANCE
AGE DEPENDENCE
BACKSCATTERING
BRAIN
CADMIUM
MENTAL DISORDERS
NEUTRON ACTIVATION ANALYSIS
PATHOGENESIS
PIXE ANALYSIS
QUANTITATIVE CHEMICAL ANALYSIS
TRACE AMOUNTS