Changes in ratios of high-molecular-weight fatty acid composition, constituting hepatic lipids in irradiated animals. 2. Differences in the metabolism of palmitic acid and linoleic acid in irradiated animals (in Japanese)
After giving whole-body irradiation of 600 R, albumin complexed-palmitic acid-1-/sup 14/C or linoleic acid-//sup 14/C were administered to mice, and the changes of metabolism in these irradiated animals were studied. For this study, amounts of /sup 14/CO/sub 2/ exhaled, specific activity of liver lipids, and activities of individual fatty acid fractions with lapse of time were measured. It was found that the incorporation of palmitic acid-1-/sup 14/C into /sup 14/CO/ sub 2/ was increa sed about 150% in the irradiated group as compared with that in controls. In contrast, that of linoleic acid-1-/sup 14/C was decreased by about 50% as compared with controls. The incorporation of palmitic acid-1-/sup 14/C into liver lipids was considerable in the early stage alter the irradiation, but it decreased rapidly and became less than that of controls within a short period of time. The uptake of linoleic acid-1-/sup 14/C into the liver of the irradiated group was found to be decreased. In the irradiated groups, data revealed an inhibitory effect on unsaturation and chain elongation of both palmitic acid and linoleic acid. (auth)
- Research Organization:
- Okayama Univ., Japan
- NSA Number:
- NSA-29-010442
- OSTI ID:
- 4362645
- Journal Information:
- Okayama Igakkai Zasshi, v. 83, no. 11-12, pp. 545-552, Journal Name: Okayama Igakkai Zasshi, v. 83, no. 11-12, pp. 545-552; ISSN OIZAA
- Country of Publication:
- Japan
- Language:
- Japanese
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*LINOLEIC ACID-- METABOLISM
ALBUMINS
BIOLOGICAL RADIATION EFFECTS
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EXHALATION
LIVER
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHOSPHOLIPIDS
TESTES
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TRACER TECHNIQUES
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WHOLE-BODY IRRADIATION