EFFECTS OF WHOLE BODY X-RADIATION ON THE ACCRETION AND EXCHANGE OF RADIOSTRONTIUM IN THE SKELETON OF DOGS
BS>An attempt was made to quantitate the effects of whole body x irradiation on the inorganic metabolism of the skeletal tissue of adult dogs. A radioisotopic tracer technique employing strontium-85 was used to differentiate in vivo between the amount of exchangeable calcium and the rate of skeletal accretion (Sr/sup 85/ incorporated into the non-exchangeable fraction) in both normal and irradiated beagles. The accretion rate was found to be inversely correlated with the age of the animals. At 10 months following exposure to 300 r (mid-line dose) whole body x irradiation, both the accretion rate and the amount of exchangeable calcium in the skeleton of the irradiated dogs were higher than in the non-irradiated controls. The results are interpreted as indicating that unlike aging the late effect of x irradiation is a stimulation of new bone formation and skeletal metabolism. At observed, however, there was a decrease in the exchangeable calcium. The latter result is interpreted as indicating that x irradiation acutely produces a depletion of the labile skeletal calcium reserves which are measurable as exchangeable calcium. (auth)
- Research Organization:
- Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-12-009574
- OSTI ID:
- 4345710
- Report Number(s):
- USNRDL-TR-219
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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