Assignment of DAP1 and DAPK: Genes that positively mediate programmed cell death triggered by IFN-{gamma}: To chromosome regions 5p12.2 and 9q34.1, respectively
- Jefferson Medical College, Philadelphia, PA (United States); and others
DAP-kinase (DAPK) and DAP1 were recently identified as positive mediators of IFN-{gamma}-induced programmed cell death. The inactivation of these genes by antisense RNA expression reduced the susceptibility of HeLa cells to IFN-{gamma}-induced apoptosis. DAP1 is expressed as a single 2.4-kb mRNA that codes for a basic proline-rich 15-kDa protein. DAPK is transcribed into a single 6.3-kb mRNA and codes for a structurally unique 160-kDa calmodulin-dependent serine-threonine kinase that carries eight ankyrin repeats and two putative P-loop consensus sites. Since genes involved in control of cell death can, when dysregulated, behave as oncogenes or growth suppressor genes, DAPK and DAP1 as positive mediators of IFN-{gamma}-induced cell death may be candidate tumor suppressor genes. Thus, knowledge of the chromosome locations of the DAP1 and DAPK genes might be useful in initial assessment of involvement in neoplasia or other diseases. 7 refs., 1 fig.
- OSTI ID:
- 433324
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 29; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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