Structure of the gene encoding the murine protein kinase CK2{beta} subunit
- Universitaet de Saarlandes, Hoburg/Saar (Germany)
The mouse protein kinase CK2{beta} subunit gene (Csnk2b) is composed of seven exons contained within 7874 bp. The exon and intron lengths extend from 76 to 321 and 111 to 1272 bp, respectively. The lengths of the murine coding exons correspond exactly to the lengths of the exons in the human CK2{beta} gene. Both genes contain a first untranslated exon. Also, the promotor regions from the human and murine CK2{beta} gene share some common features, e.g., they contain neither a TATA nor a CAAT box, exon 1 is flanked by a cluster of CpG dinucleotides and recognition sequences for the HpaII restriction endonuclease, and several blocks of sequence in the 5{prime} flanking region are conserved between mouse and human. Despite all of these common features, one of the most striking differences found concerns the human CK2{alpha} subunit binding domain has no counterpart in the murine gene. Hence, regulation of transcription of the CK2{beta} gene by the catalytic CK2{alpha} subunit as was described by Robitzki et al. for the human gene cannot be considered a general regulatory mechanism. 14 refs., 3 figs.
- OSTI ID:
- 433309
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 29; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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