THE RELATIVE EFFECTS OF DIRECT AND INDIRECT ACTIONS OF IONIZING RADIATIONS ON DEOXYRIBO-NUCLEIC ACID

Journal Article · Tue Jul 01 04:00:00 EDT 1958 · Proc. Roy Soc. (London)

DOI:https://doi.org/10.1098/rspb.1958.0047· OSTI ID:4332061

Butler, J A.V.; Pain, R H; Robins, A B; Rotblat, J

The effectiveness of ionizing radiations in damaging the DNA particle. as determined by the number of primary ionizations in the volume occupied by each particle, which is required to reduce the intrinsic viscosity to half its original value has been determined over a range of concentrations from 0.01 to 100%. The different specimens of DNA employed differ considerably in sensitivity, but with each specimen the number of ionizations required is approximately constant from 1 to 100%. This means that over this range of concentration an ionization occurring in the water has the same effect as one within the DNA particle. The differences of sensitivity of the different samples are probably due to traces of protein contamination and disappear at the greater dilutions. The effects were independent of the dose rate and of the hardness of the radiations within the ranges used and identical effects were obtained with electrons and x rays. (auth)

• Research Organization: Chester Beatty Research Inst., London; St. Bartholomew's Hospital Medical Coll., London
• Sponsoring Organization: USDOE
• NSA Number: NSA-12-013795
• OSTI ID: 4332061
• Journal Information: Proc. Roy Soc. (London), Journal Name: Proc. Roy Soc. (London) Vol. Vol: B149
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

CHEMISTRY
CONCENTRATION
DNA
ELECTRON BEAMS
ELECTRONS
GAMMA RADIATION
IMPURITIES
IONIZATION
NUCLEIC ACIDS
PARTICLES
PROTEINS
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION CHEMISTRY
RADIATION DOSES
RADIATION EFFECTS
RIBONUCLEIC ACID
SENSITIVITY
TRACE AMOUNTS
VISCOSITY
WATER
X RADIATION