Radiation-induced changes in glomerular and tubular cell kinetics and morphology following irradiation of a single kidney in the pig

Journal Article · Sat Jul 15 04:00:00 EDT 1995 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/0360-3016(95)00548-D· OSTI ID:433190

Robbins, M E.C.; Bonsib, S M; Ikeda, A ^[1]

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1. Univ. of Iowa, Iowa City, IA (United States); and others

Radiation-induced changes in glomerular and tubular cell kinetics and morphology following irradiation of a single pig kidney were assessed. Irradiation of the right kidney alone resulted in a significant increase in renal cell labeling index (LI) in both the irradiated and the contralateral unirradiated kidney within 2 weeks of irradiation; peak values of 1.57 {plus_minus} 0.32% and 1.04 {plus_minus} 0.13%, respectively, were seen 4 weeks PI, significantly greater (p < 0.001) than the preirradiation value of 0.18 {plus_minus} 0.01%. The LI values then declined with time, but remained greater than those seen prior to irradiation. A similar pattern of response was determined from counts of labeled glomerular and tubular cells identified immunohistochemically. The increase in labeled glomerular cells was seen 2 weeks postirradiation (PI), whereas that for the tubular cells did not occur until 4 weeks PI. The irradiated kidney exhibited diffuse, progressive glomerular alterations. In contrast, tubular damage was focal; the irradiated kidney also exhibited a prominent vasculopathy, involving arteriolar and peripheral interlobular artery thickening. The contralateral unirradiated kidney appeared unchanged. These findings confirm the hypothesis that the morphologic and kinetic responses observed after irradiation of a single kidney are similar to those observed after irradiation of both kidneys. Renal irradiation results in significant alterations in glomerular and tubular cell proliferation and morphology within 2-4 weeks of irradiation; glomerular changes appear predominant. 35 refs., 7 figs., 1 tab.

• OSTI ID: 433190
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 4 Vol. 32; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ANIMAL CELLS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BUDR
CELL CYCLE
CELL FLOW SYSTEMS
CELL PROLIFERATION
DELAYED RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
GAMMA RADIATION
GLOMERULI
MORPHOLOGICAL CHANGES
SWINE
UROGENITAL SYSTEM DISEASES