THE INHIBITION OF THE UPTAKE OF RADIOPHOSPHATE IN NORMAL AND SICKLE ANEMIC RED BLOOD CELLS

Journal Article · Wed Jan 01 00:00:00 EST 1958 · Intern. J. Appl. Radiation and Isotopes

DOI:https://doi.org/10.1016/0020-708X(58)90002-4· OSTI ID:4330387

Labat, G P; Branson, H

Through the use of P/sup 32/ a coefficient of transfer and a coefficient of inhibition of transfer are defined precisely for the transport of phosphate into the human red blood cell. The method is applied to a study of the inhibitory effect of sodium fluoride on the uptake of radiophosphate by sickle cell red blood cells. The data reveal that there may be an intrinsic quality in the sickle cell which is different in the normal cell since the rate of transfer of phosphate in the sickle cell is the same with or without sodium fluoride while transport in the normal red blood cell is strongly inhibited by fluoride. (auth)

• Research Organization: Howard Univ., Washington
• NSA Number: NSA-12-008986
• OSTI ID: 4330387
• Journal Information: Intern. J. Appl. Radiation and Isotopes, Vol. Vol: 3; Other Information: Orig. Receipt Date: 31-DEC-58
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
ANEMIA
DISEASES
DISTRIBUTION
ERYTHROCYTES
MAN
METABOLISM
PHOSPHATES
PHOSPHORUS 32
SODIUM FLUORIDES
TRACER TECHNIQUES
USES
VARIATIONS