Evidence for in vivo protection against murine-sarcoma virus-induced tumors by T lymphocytes from immune animals
Normal 3- to 4-week old BALB/c mice inoculated with murine sarcoma virus (MSVI develop sarcomas within 7 to 10 days, which generally regress by day 15 to 20. Sublethal irradiation of the recipieats, prior to inoculation of MSV, leads to the development of progressively growing tumors and ultimate death of the host within 30 days. Snnall nunnbers (1 x 10/sup 7/) of spleen cells from mice whose tumor has regressed, but not similar numbers of cells from age-matched control mice. protect these irradiated mice from develoing progressively growing tumors. Pretreatment of the protecting cells with anti- theta antibody and complement, but not with anti-immunoglobulin antibody and complement, abolishes the protective effect. (auth)
- Research Organization:
- London Univ.
- NSA Number:
- NSA-29-021191
- OSTI ID:
- 4328119
- Journal Information:
- J. Immunol., v. 112, no. 2, pp. 533-539, Other Information: Orig. Receipt Date: 30-JUN-74
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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