Radiation-induced changes in skeletal muscle. An electron microscopic study
Ultrastructural aspects of skeletal muscle changes in rabbits after local exposure to 1,130 R and 1,300 R of x-ray irradiation are presented. s spectrum of multifocal lesions of muscle cells and microvasculature appearing simultaneously as early as 24 hrs. and followed up to day 40 post-irradiation is described. Muscle cell changes were characterized by myofibrillolysis, myonecrosis followed by appearance of muscle buds, focal increase in glycogen content of relatively intact fibers, and myofiber atrophy and degeneration. Suggestive evidence for intracellular regeneration followin myofibrillolysis is presented. Microvasculature showed progressive endothelial cell swelling with increased pinocytotic activity and accelerated transport of ferritin followed by a peculiar metaplastic change characterized by well developed Golgi complex and endoplasmic reticulum. Delayed fibrinoid necrosis of capillaries observed on day 28 probably resulted from toxic products released from degenerating and necrotic muscle and mesenchymal cells, and its probable role in delayed myonecrosis is discussed. Radiation induced myopathic changes seem to follow direct radiation injury and complex phenomena of interaction from chanes in individual structural components of muscle. (auth)
- Research Organization:
- New Jersey Medical School, Newark
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-29-021217
- OSTI ID:
- 4328070
- Journal Information:
- J. Neuropathol. Exp. Neurol., v. 33, no. 1, pp. 42-57, Other Information: Orig. Receipt Date: 30-JUN-74
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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