Quantitative study of late radiation effect on normal skin and subcutaneous tissues in human beings
A retrospective study of late effects of irradiation on skin and underlying connective tissues in 94 testis tumor patients was conducted 5 to 8 years after irradiation. The late lesions were classm-fied into five degrees of severity of injury. Among this population of patients, there was marked variation of severity of injury produced by similar dosage; or when viewed differently, each degree of severity of injury was produced by a wide range of doses. Therefore, since the late response of connective tissues was not constant, a tolerance dose could not be established, but only a percent probability of threat of a speciflc degree of injury. Within certain limits, the late effects were independent of overall time and dependent on the size of the daily fraction. Biological features of non-proliferating connective tissue were not applicable to dynamically proliferating normal epithelial and cancerous tissues. (auth)
- Research Organization:
- Istituto Regina Elena, Rome
- NSA Number:
- NSA-29-024489
- OSTI ID:
- 4307281
- Journal Information:
- Brit. J. Radiol., v. 47, no. 553, pp. 44-50, Journal Name: Brit. J. Radiol., v. 47, no. 553, pp. 44-50; ISSN BJRAA
- Country of Publication:
- United Kingdom
- Language:
- English
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