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Production of Sterility in Mice by Deuterium Oxide

Journal Article · · Science
Sterility was induced in both male and female mice following the substitution of D2O for a part of the drinking water. Doses of 5 to 30% deuterium oxide were administered. C57 and Swiss mice were used and both strain and sex differences in response to D2O were noted. No significant differences were noted in litter size or sex ratio from that of the controls. Several physiological mechanisms by which D2O produces sterility in mice are suggested.
Research Organization:
Univ. of California, Berkeley
Sponsoring Organization:
USDOE
NSA Number:
NSA-12-011283
OSTI ID:
4304035
Journal Information:
Science, Journal Name: Science Journal Issue: 3312 Vol. 127; ISSN 0036-8075
Publisher:
AAAS
Country of Publication:
Country unknown/Code not available
Language:
English

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