Toxicity of 2,3,7,8-TCDD to brook trout offspring following long-term dietary exposure to parents
- Environmental Protection Agency, Duluth, MN (United States)
Adult brook trout were exposed via diet to [1,6-H{sup 3}] 2,3,7,8-TCDD (TCDD). The exposure, which began 15 July 1993, had a 4-week loading phase, to bring the adults to a specified TCDD residue, and a maintenance phase, to hold the fish at the desired TCDD level until spawning. Artificial spawning substrates were placed within tanks containing 2 male and 3 female fish. After the fish spawned, the eggs were removed from the artificial substrate and samples were taken for determination of TCDD residues, and lipid content. The remainder were incubated at 6.8--7.0 C to determine the effects of TCDD on egg, embryo, and fry development and survival. The most important endpoint monitored was the cumulative mortality induced by maternally derived TCDD residues. The effects of TCDD residues (total and lipid normalized) on eggs, embryos, and fry, will be presented. Lethal residues responsible for 50% mortality (LR{sub 50}) were determined. Descriptions of TCDD induced toxicity syndromes on brook trout will also be presented.
- OSTI ID:
- 42911
- Report Number(s):
- CONF-9410273--
- Country of Publication:
- United States
- Language:
- English
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