THE INFLUENCE OF DEUTERATION ON THE PROPERTIES OF SOME BIOLOGICALLY ACTIVE ORGANIC MOLECULES

Technical Report · Sat Oct 31 04:00:00 EST 1959

OSTI ID:4290614

Buu-Hoi, N P; Xuong, N D

Deuterium has hitherto been utilized mostly for the labeling of molecules, but the intrinsic properties of deuterated compounds have only rarely been investigated. In the framework of a vast program of investigation of deuteratred and tritiated organic compounds of known structure, a large number of substances containing a high proportion of deuterium in place of hydrogen have now been synthesized, and their biological properties assessed comparatively with those of their hydrogen analogs. Thus, convenient methods of synthesis have been devised for the preparation of diverse types of molecules, including straight chain and ramified fatty acids (some examples being the hexadeuteriova, leric acid of formula CHD/sub 2/-(CHD)/sub 3/-CD/sub 2/-CO/sub 2/H, the octadeuterioheptoic acid of formula CHD/sub 2/-- (CHD)/sub 2/ -taberculostearic acid of formula CH/sub 2/-- CHD/sub 2/-- (CHD)/sub 2/-CD/sub 2/-(CHD)/sub 2/-CH/ sub 2/-CH(CH/sub 3/)-CH/sub 2/-CD/sub 2/- (CHD/sub 2/CD/sub 2/estrogens (e.g., a penta- and a decadeuterated derivative of a-bromotriphenylethylene), carcinogens, mitoclastic compounds and plant hormones, etc., all of them entirely or largely deuterated in well-defined positions. In many instances the biological properties displayed by the deuterated molecule were noticeably different, not only quantitatively but also qualitatively, from those of the nondeuterated compound. Some of the manifold prospects for the practical applications of these findings in medicine and in industry are discussed. (auth)

• Research Organization: Republic of Vietnam
• NSA Number: NSA-13-006418
• OSTI ID: 4290614
• Report Number(s): A/CONF.15/P/2340
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALCOHOLS
BIOCHEMISTRY
BIOLOGY
BROMINATED HYDROCARBONS
CARCINOGENESIS
CHEMICAL REACTIONS
CHEMISTRY
COMPOUNDS
CRYSTALS
DEUTERIUM
DEUTERIUM COMPOUNDS
ESTERS
ETHYLENE
HORMONES
HYDROGEN
ISOTOPE EFFECTS
LABELLED COMPOUNDS
LATTICES
MEASURED VALUES
MEDICINE
ORGANIC ACIDS
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
PHENYL RADICALS
PLANTS
PREPARATION
TRITIUM
USES
VALERIC ACID