DIFFERENTIAL DISTRIBUTION OF RADIOACTIVE STRONTIUM AND YTTRIUM IN THE TISSUES OF THE RABBIT'S EYE

Journal Article · Sat Mar 21 04:00:00 EST 1959 · Nature

DOI:https://doi.org/10.1038/183802a0· OSTI ID:4289994

Mole, R H; Pirie, A; Vaughan, J M

BS>Weanling rabbits were injected intravenously with an equilibrium mixture of strontium-90 and ytrrium-90 or with yttrium-91 in doses of between 72 and 600 mu c/kg body-weight and killed at various intervals of time thereafter. Some of the animals were given a daily dose of strontium-90 by mouth. Investigations were to determine the concentration of the isotopes in different tissues of the eyes. All parts of the rabbit's eye, except the tens, accumulated strontium-90 to a greater degree than striated muscle, a representative soft tissue. The pigmented parts accumulated most, the iris having 0.5 per cent of the concentration in the femur at 9 to 30 days when redistribution was approaching completion. There were much bigger differences between physiologically different parts of the eye in their retention of strontium-90. Yttrium-90 and strontium-90 were rarely in equilibrium in any part of the eye at any time after administration of an equilibrium mixture. The retina maintained the largest excess of yttrium-90, although its direct uptake of yttrium-91 was small. (J.H.M.)

• Research Organization: Medical Research Council Radiobiological Research Unit, Harwell, Berks, Eng.; Univ. of Oxford; Churchill Hospital, Oxford
• Sponsoring Organization: USDOE
• NSA Number: NSA-13-009631
• OSTI ID: 4289994
• Journal Information: Nature, Journal Name: Nature Vol. Vol: 183
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BONES
DISTRIBUTION
EYES
LENSES
MUSCLES
NERVOUS SYSTEM
PIGMENTS
QUANTITY RATIO
RABBITS
RETINA
STRONTIUM 90
TISSUES
YTTRIUM 90
YTTRIUM 91