THE DOSAGE RESPONSE CURVE FOR RADIATION INDUCED DOMINANT LETHAL MUTATIONS IN THE HONEYBEE

Journal Article · Tue Jul 01 04:00:00 EDT 1958 · Genetics (U.S.)

OSTI ID:4282139

Lee, W R

The dosage of gamma radiation required to inactivate honeybee sperm is several fold higher than the nearly 100 percent domxaminant lethal dosage, as in Habrobracon. Nearly all the induced dominant lethals cansed death in the egg stage. The proportion of dominant lethals in irradiated spermatozoa did not change after one year of storage in the spermatheca of the queen. There was no significant fractionation effect, the percentage of dominant lethals being the same when 2,000 r were given in a continuous dose as when given in two equal fractions separated by one hour. The curve relating dominant lethals to dosages is in quantitative agreement with those of Drosophila and Habrobracon. It shows a highly significant departure from linearity (after correction for natural mortality and saturation), but approaches linearity at low dosages. This is consistent with the hypothesis that dominant lethals are due primarily to single chromosome breaks at low dosages and multiple break phenomena at higher dosages. (auth)

• Research Organization: Univ. of Wisconsin, Madison
• NSA Number: NSA-13-001913
• OSTI ID: 4282139
• Journal Information: Genetics (U.S.), Journal Name: Genetics (U.S.) Vol. Vol: 43; ISSN GENTA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CHROMOSOMES
DROSOPHILA
EGGS
GAMMA RADIATION
GENETICS
GONADS
HABROBRACON
INSECTS
LETHAL DOSE
MEASURED VALUES
MUTATIONS
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
SPERM
STORAGE