ON THE PRIMARY MECHANISM OF THE BIOLOGICAL EFFECT OF RADIATION

Journal Article · Sun Mar 01 04:00:00 EST 1959 · Izvest. Akad. Nauk S.S.S.R., Ser. Biol.

OSTI ID:4281750

Shekhtman, J L

The derangement of the mitotic capacity of the cell as caused by radiation is primarily associated with the cell nucleus rather than with cytoplasm. In contrast to cytoplasmic structures, the nucleoprotein structures of the nucleus are unique, and local injury of evcn a single structure calls forth profound disturbances of the rhythm and sequence of the multiplication processes of nucleic acids and of protein synthesis. The capacity of the cell to normal division is thereby lost and the cell dies, eventually after several atypical divisions. In the embryonlc material lrradiated at early stages of development distinct maxima and minima of radiosensitivity are noted corresponding to certain phases of karyokinesis. Analysis of radiosensitivity of two cultures of B. coll the normal and glucose one, irradiated with x rays and alpha rays of polonium has revealed certain regularities which suggest the presence in the glucose culture of a polyploid structure of nuclear substance. These findings comply with similar results obtained by Ogg and Zelle in the camphor and normal culture of B. coli. Thus it appears that most promising for the protection and therapy of the radiation disease are those methods which are based on the stimulation of the reparative processes within the irradiated organism, such as the use of emulsions of bone marrow tissue, transfusion of blood and of its substitutes, and transplantation of organs. (auth)

• Research Organization: Inst. of Biological Physics, Academy of Sciences of the USSR, Moscow
• NSA Number: NSA-13-010805
• OSTI ID: 4281750
• Journal Information: Izvest. Akad. Nauk S.S.S.R., Ser. Biol., Journal Name: Izvest. Akad. Nauk S.S.S.R., Ser. Biol. Vol. Vol: No. 2
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ALPHA DECAY
BACTERIA
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BLOOD
BONE MARROW
CAMPHOR
CELL NUCLEI
CULTURES
CYTOLOGY
EMBRYOS
ESCHERICHIA COLI
KETONES
MICROORGANISMS
MITOSIS
MUTATIONS
NUCLEIC ACIDS
POLONIUM
PROTEINS
RADIATION EFFECTS
RADIATION PROTECTION
RADIOBIOLOGY
RADIOSENSITIVITY
SUGARS
TERPENES
TISSUES
TRANSFUSIONS
TRANSPLANTS
VARIATIONS
X RADIATION