EFFECTS OF PRENATAL X-IRRADIATION ON TESTICULAR FUNCTION AND MORPHOLOGY IN THE RAT
Present findings confirm and extend the observations of Kosaka and Hanson that x irradiation during certain stages of prenatal development results in testicular injury and infertility in the male rat. The effects were particularly marked in the offspring of rats irradiated on the 18th day of pregnancy. These rats also showed in addition to testes injury a significant reduction in seminal vesicle weight. Testicular injury also occurred in the offspring of rats irradiated on the 14th day of pregnancy but was less marked than in the 18-day series. No abnorinalities in testicular function or morphology were observed in the offspring of rats irradiated on the 10th day of pregnancy. The present investigation was conducted with doses of x-irradiation that were more clearly defined, with time of irradiation more clearly delineated, and with a larger number of animals per group than was the case in earlier studies. (auth)
- Research Organization:
- Western Biological Labs., Culver City, Calif.
- NSA Number:
- NSA-13-011547
- OSTI ID:
- 4276922
- Journal Information:
- American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 196; ISSN AJPHA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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