A SEROLOGICAL AND ELECTROPHORETIC STUDY OF DIPHTHERIA ANTISERA IRRADIATED WITH STERILIZING DOSES OF $gamma$-RAYS
The effects of irradiation on the antitoxic, anaphylactic, and electrophoretic properties of diphtheria antisera were studied at the various doses used for sterilization. Both crude and purified diphtheria antitoxic antisera were used. Irradiations were carried out with a cobalt-60 source with a total power of 5 kc. The dosage rate was 600 r/min. Data are tabulated. The results demonstrate considerable changes in the properties of antisera taking place as a result of exposure to large doses of gamma radiation. In all experiments a regular fall in the antitoxin titre was demonstrated. A greater destruction of antitoxin was observed in the crude antiserum than in the purified. Possible reaction mechanisms involved are discussed. (C.H.)
- Research Organization:
- Gamaleia Inst. of Epidemiology and Microbiology, Academy of Medical Sciences, U.S.S.R.
- NSA Number:
- NSA-13-012393
- OSTI ID:
- 4267641
- Journal Information:
- J. Microbiol. Epidemiol. Immunobiol. (USSR) (English Translation), Vol. Vol: 29; Other Information: Orig. Receipt Date: 31-DEC-59
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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