RADIATION SICKNESS IN MAMMALS FOLLOWING IRRADIATION OF THE FACIAL PART OF THE HEAD
In 232 guinea pigs the authors studied processes which developed after irradiation of different parts of the head with doses of 2,400 to 20,000 r. Irradiation of the whole head or of the facial part only, with doses of 2,500 to 4,000 r led to acute radiation sickness, with death of 50 to 100% of the animals at a given stable time (7 to 10 days). Under these conditions, marked leucopenia (2,500 to 3,000 cells mm/sup 3/), moderate hypoplasia of non-irradiated hematopoietic tissue, marked involution of the thymus gland, hyperplasia of the adrenals and thinning of the mucous membrane of the small intestine were observed. Irradiation of the cerebral area with the same doses, or with doses up to 10,000 r, did not lead to the development of acute radiation sickness or to death. Severe radiation injury was observed at the site of irradiation. The development of severe radiation sickness and death following irradiation of the facial part of the head, without direct irradiation of vital organs, is important evidence supporting the hypothesis of the reflex mechanism of the development of acute radiation sickness. (auth)
- Research Organization:
- Inst. of Experimental Pathology and Therapy, U.S.S.R., Academy of Medical Sciences, Suchumi
- NSA Number:
- NSA-13-017696
- OSTI ID:
- 4264277
- Journal Information:
- Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 5; ISSN FOBLA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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