Occurrence of the Cys311 DRD2 variant in a pedigree multiply affected with panic disorder

Journal Article · Mon Aug 14 00:00:00 EDT 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320600414· OSTI ID:426179

Crawford, F; Hoyne, J; Diaz, P ^[1]

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1. Univ. of South Florida, Tampa, FL (United States); and others

Following the detection of the rare DRD2 codon 311 variant (Ser{yields}Cys) in an affected member from a large, multiply affected panic disorder family, we investigated the occurrence of this variant in other family members. The variant occurred in both affected and unaffected individuals. Further screening in panic disorder sib pairs unrelated to this family failed to detect the Cys311 variant. Our data suggests that this variant has no pathogenic role in panic disorder. 18 refs., 1 fig.

• Sponsoring Organization: USDOE
• OSTI ID: 426179
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 4 Vol. 60; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMINO ACIDS
CODONS
DOPAMINE
GENE MUTATIONS
GENES
GENETIC MAPPING
GENETICS
GENOTYPE
HEREDITARY DISEASES
MENTAL DISORDERS
PATHOGENESIS
PATIENTS
RECEPTORS