THE CHEMICAL ENHANCEMENT OF BACTERIAL RADIOSENSITIVITY IN THE RADIATION STERILIZATION FOODS. Report No. 12 (Final) for September 1, 1955-December 31, 1957
A number of compounds were found to be synergistic or complementary with x irradiation in the inactivation of spores of Bacillus thermoacidurans, B. subtilis, and B. cereus. The synergism involving ethylene oxide was studied in some detail using B. thermoacidurans and B. subtilis. Propylene oxide showed a similar synergistic effect. Also, alpha-amino-n-butyric acid was synergistic with radiation on B. cereus spores. A number of compounds were complementary with x irradiation in the inactivation of spores. For instances sorbic acid, sodium diacetates 1,2-propanediols benzylalkonium chloride ("Roccal"), malonic acids maleic acids sodium desoxycholate. B. subtilis spores were more radioresistant than those of B. cereus or B. thermoacidurans; the respective D/ sub o/ values were about 150,000, 80,000, and 50,000 rads. Fluid milk and fresh meats were sterilized by combined radiation and dilute ethylene oxide treatment using 100,000 rads or less of ionizing radiation. While the sterilized foods were normal in appearance and tastes no attempt was made to determine their wholesomeness. Indeed, the main objective of this phase was the establishment of a bacteriological baseline; the selection of the most appropriate agent will require further investigation. Propylene oxide should be explored since it too is volatile and its glycol is metabolizable and harmless, whereas ethylene glycol is toxic. The need for additional knowledge concerning factors involved in the radiation sensitivity of micro-orgamisms has been evident throughout this investigation. More information on the mechanism of radiation resistance, especially in bacterial spores, should be most helpful to the radiation preservation program. (auth)
- Research Organization:
- Syracuse Univ., N.Y. Biological and Food Research Center; Syracuse Univ., N.Y. Research Inst. Page(s): 72
- DOE Contract Number:
- DA-19-129-QM-524
- NSA Number:
- NSA-13-014131
- OSTI ID:
- 4261073
- Report Number(s):
- AD-201602
- Resource Relation:
- Other Information: Project No. 7-84-01-002. Orig. Receipt Date: 31-DEC-59
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ACETATES- CHEMICALS- CYTOLOGY- MALEIC ACID- MALONIC ACID- MICROORGANISMS- ORGANIC ACIDS- ORGANIC COMPOUNDS- RADIOSENSITIVITY- SODIUM COMPOUNDS- SORBIC ACID- VARIATIONS- X RADIATION
ALCOHOLS- BACILLUS CEREUS- BACILLUS SUBTILIS- BACILLUS THERMOACIDURANS- BACTERIA- CYTOLOGY- ETHYLENE- FOOD- GLYCOLS- MEAT- METABOLISM- MICROORGANISMS- MILK- OXIDES- PRESERVATION- PROPYLENE- RADIATION DOSES- RADIATION EFFECTS- RADIOSENSITIVITY- - SOLUTIONS- SPORES- STERILIZATION- TOXICITY- VARIATIONS- VOLATILITY- X RADIATION
BACILLUS CEREUS- BACILLUS SUBTILIS- BACILLUS THERMOACIDURANS- BACTERIA- BUTYRIC ACID- CHEMICALS- CY