Growth abnormalities in the population exposed in utero and early postnatally to polychlorinated biphenyls and dibenzofurans
- National Cheng Kung Univ. Medical College, Tainan (Taiwan, Province of China)
- UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ (United States)
This article reviews the findings in children exposed to various levels of polychlorinated biphenyls (PCBs) and related compounds in utero and early postnatally. Yu-Cheng ({open_quotes}oil-disease{close_quotes}) mothers were Taiwanese women exposed to PCBs and their heat-degradation products form the ingestion of contaminated rice oil in 1979. Children of these mothers were born growth retarded, with dysmorphic physical findings, and delayed cognitive development compared with unexposed children. In this article, findings in Yu-Cheng children born between 1978 and 1985 are summarized and compared with two other well-documented cohorts of children prenatally exposed to different levels of PCBs. Results of the investigation in Yu-Cheng children will provide important information about the toxicities, health effects, and mechanisms of PCB/PCDF exposure and demonstrate that the developing human is more sensitive than the adult to the toxic effects of these chemicals. 53 refs., 2 tabs.
- OSTI ID:
- 426042
- Journal Information:
- Environmental Health Perspectives, Journal Name: Environmental Health Perspectives Journal Issue: Suppl.6 Vol. 103; ISSN 0091-6765; ISSN EVHPAZ
- Country of Publication:
- United States
- Language:
- English
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