Elevated incidence of childhood leukemia in Woburn, Massachusetts: NIEHS Superfund Basic Research Program searches for causes

Journal Article · Fri Sep 01 04:00:00 EDT 1995 · Environmental Health Perspectives

DOI:https://doi.org/10.1289/ehp.95103s693· OSTI ID:426041

Durant, J L; Chen, J; Hemond, H F; Thilly, W G ^[1]

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1. Massachusetts Inst. of Technology, Cambridge, MA (United States)

Between 1966 and 1986, the childhood leukemia rate in Woburn, Massachusetts, was 4-fold higher than the national average. A multidisciplinary research team from MIT, which is being supported by the NIEHS Superfund Basic Research Program, has explored the possible importance of a temporal correlation between the period of elevated leukemia and a previously unrecognized mobilization of toxic metals from a waste disposal site in north Woburn. Residents of Woburn may have been exposed to arsenic (70 {mu}g/l) and chromium (240 {mu}g/l) at levels in excess of federal drinking water standards (50 {mu}g/l for each metal) by consuming municipal groundwater contaminated with these metals. Research is currently underway (a) to elucidate the mechanisms and the pathways by which these metals were transported form the waste disposal site to the drinking water supply; (b) to determine the identity of the principal human cell mutagens in samples of aquifer materials collected form the site of the municipal supply wells; and (c) to measure the extent of exposure and genetic change in residents who consumed the contaminated well water. 11 refs., 11 figs., 1 tab.

• Sponsoring Organization: USDOE
• OSTI ID: 426041
• Journal Information: Environmental Health Perspectives, Journal Name: Environmental Health Perspectives Journal Issue: Suppl.6 Vol. 103; ISSN EVHPAZ; ISSN 0091-6765
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL EFFECTS
CHILDREN
CHROMIUM
ENVIRONMENTAL EXPOSURE
HAZARDOUS MATERIALS
LEUKEMIA
US SUPERFUND