INDUCTION OF MOUSE LEUKAEMIA WITH PURIFIED NUCLEIC ACID PREPARATIONS

Journal Article · Sat Dec 21 04:00:00 EST 1957 · Nature

DOI:https://doi.org/10.1038/1801419b0· OSTI ID:4255335

Hays, E F; Simmons, N S; Beck, W S

The incidence of leukemia was increased in mice of three strains by the injection into newborn mice of cell-free extracts of nucleic acid preparations from a high-leukemia donor strain. These preliminary results in hybrid animals suggest that free nuoleic acid is leukemogenic, although the possibility is not ruled out that a virus or provirus is, in fact, the active agent in cell-free extracts, and that the preparations contained active virus nucleic acid. It is unlikely, however, that intact active virus could survive the nucleic acid isolation procedure. (C.H.)

• Research Organization: Univ. of California, Los Angeles
• Sponsoring Organization: USDOE
• NSA Number: NSA-13-010808
• OSTI ID: 4255335
• Journal Information: Nature, Journal Name: Nature Vol. Vol: 180
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
CARCINOGENESIS
LEUKEMIA
MICE
NUCLEIC ACIDS
SEPARATION PROCESSES
TRANSPLANTS
VIRUSES