STUDIES ON THE TOXICOLOGY OF AURIN TRICARBOXYLIC ACID
The acute and chronic toxicity of a relatively pure (50%) preparation of aurin tricarboxylic acid (ATA) has been studied in several animal species. The acute toxicity of ATA, administered in single doses to the rats rabbits or mouse by several routes of administration, was relatively low. The lethal dose varied from 0.48 to 3.0 gm/kg depending on the specics and route used. When ATA was injected intravenously in mice one hour after a previous intravenous injection of beryllium a marked reduction in deaths due to acute beryllium poisoning was observed. Rats exposed to atmospheres containing higly concentrations of ATA for periods as long as 20 hours showed no evidence of a toxic respouse. Repeated daily intraperitoneal injections of ATA in rats at dosages of 30 mg/kg or greater resulted in some hematological changes. No evidence of toxicity was observed in rats which ingested for a 6-month period diets containing concentrations of ATA as high as 1%. Dietary concentrations of 3 or 5% of ATA produced hematologcal changes without affecting growth or producing tissue injury. Rats fed a diet containing 10% ATA for a 49-day period failed to grow. Moderate to severe injury to the kidney glomerulus was observed when dogs were treated with ATA at doses of 2 or 20 mg/kg administered every other day for a period of one year. (auth)
- Research Organization:
- Rochester, N.Y. Univ. Atomic Energy Project
- DOE Contract Number:
- W-7401-ENG-49
- NSA Number:
- NSA-13-014985
- OSTI ID:
- 4248853
- Report Number(s):
- UR-542
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-59
- Country of Publication:
- United States
- Language:
- English
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