DEPOSITION AND RETENTION OF FLUORIDE AND RADIOCALCIUM IN THE GROWING RAT

Journal Article · Wed Jul 01 04:00:00 EDT 1959 · American Journal of Physiology (U.S.)

OSTI ID:4247883

Likins, R C; Scow, R O; Zipkin, I; Steere, A C

Radiocalcium and fluoride were administered daily for 30 days to young rats. At 30 and 60 days, the tibia, femur, mandible, teeth and remaining skeleton were analyzed for Cats and F. The tibia was divided into several segments including the proximal epiphysis, the original diaphyseal segment, and those portions of the diaphysis added from 0 to 30 days and 30 to 60 days. Fluoride had no effect on the Ca/sup 45/ or ash of bone but reduced Ca/sup 45/ uptake by molar enamal. Ratios of F to Ca/sup 45/ were dissimilar in the various tibial segments. Between 30 and 60 days essentially no Ca/sup 45/ or F was lost from the skeleton, tibia or tibial segments excepting the 0-30-day proximal diaphyseal increment. Seventy per cent of the Ca/sup 14/ and forty per cent of the F lost from this segment was found in the adjacent segment formed during the second 30-day period. These results suggest that much of the Ca/sup 45/ and F released during remodeling of the ends of the growing bone did not enter the general circulation, but was deposited in the immediate vicinity. (auth)

• Research Organization: National Institute of Health, Bethesda, Md.
• NSA Number: NSA-13-015856
• OSTI ID: 4247883
• Journal Information: American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 197; ISSN AJPHA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BLOOD CIRCULATION
BONES
CALCIUM 45
DISTRIBUTION
FLUORIDES
FLUORINE
METABOLISM
PHYSIOLOGY
QUALITATIVE ANALYSIS
QUANTITY RATIO
RATS
RESIDUES
TEETH
VARIATIONS