The effect of ionizing radiation on nuclear phosphorylation in the radio-sensitive tissues of the rat
When nuclei prepared from spleen, thymus gland, lymph node, bone marrow, and intestinal mucosa of the rat are shaken aerobically at 0 deg in a suitable medium, acid-labile phosphate is formed. This is not so for the radio- insensitive tissues such as brain, liver, kidney, and pancreas. Low doses of whole-body x irradiation abolish the nuclear phosphorylation. Low doses of gamma irradiation given to suspensions of nuclei also prevent nuclear phosphorylation. In spleen and thymus there is a recovery of the ability to effect nuclear phosphorylation at about 100 hr after 100 r of total-body radiation. The possible significance of the observations in relation a the radio- biological lesion is discussed. (auth)
- Research Organization:
- Oxford Univ.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-13-018817
- OSTI ID:
- 4235970
- Journal Information:
- Biochemical Journal, Journal Name: Biochemical Journal Journal Issue: 3 Vol. 72; ISSN 0264-6021
- Publisher:
- Biochemical Society
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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